Antipsychotics

Vivian Imbriotis | June 19, 2026

$$\begin{array}{llll} \textbf{Feature} & \textbf{Haloperidol} & \textbf{Olanzapine} & \textbf{Quetiapine} \\ \hline \text{D2 affinity (antagonist)} & \text{high} & \text{mid} & \text{low} \\ \text{Other receptors blocked} & - & 5HT2\text{ (treats neg symptoms)} & 5HT2 \\ & & H1\text{ (sedation)} & H1 \\ & & \uparrow\uparrow M1\text{ (anticholinergic)} & \uparrow M1 \\ & & & \alpha_1\text{ (sedation)} \\ \text{EPS risk} & \text{high} & \text{mid} & \text{low} \\ \text{Sedation} & \text{low} & \text{mid} & \text{high} \\ \text{Metabolic syndrome} & \text{low} & \text{high} & \text{mid} \\ \text{Prolactinaemia} & \text{high} & \text{mid} & \\ \text{QTc prolongation} & \text{mid} & \text{low} & \text{high} \\ \text{NMS risk} & \text{high} & \text{mid} & \text{low} \end{array}$$